RESEARCH OUTPUT

Selected publications

Discoveries that shape our research.

Selected publications Full publication list

2026IMMUNOMETABOLISM

Nature Communications 17, 9805

Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice

Yu YC, Sung Y, Lim SH, et al. · Han JM*

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2025DRUG DISCOVERY

Nature Communications 16, 9690

Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var

Sung Y, Yu YC, Lee M, et al. · Han JM*

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2023CANCER METABOLISM

Cancer Research 83(5), 735–752

Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer

Park SJ, Yoo HC, Ahn E, et al. · Han JM*

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2022NUTRIENT SENSING

Nature Communications 13, 2904

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

Kim K, Yoo HC, Kim BG, et al. · Kim S*, Han JM*

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2020REVIEW · GLUTAMINE METABOLISM

Most-cited publication from our lab

Experimental & Molecular Medicine 52, 1496–1516

Glutamine reliance in cell metabolism

A review of glutamine's roles in biosynthesis and bioenergetics, linking compartmentalized metabolism with epigenetic regulation and opportunities for cancer therapy.

Yoo HC, Yu YC, Sung Y, Han JM*

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2020MITOCHONDRIAL TRANSPORT

Cell Metabolism 31(2), 267–283

A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells

Yoo HC, Park SJ, Nam M, et al. · Han JM*

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2020METABOLIC CONTROL

Science 367(6474), 205–210

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

Yoon I, Nam M, Kim HK, et al.

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2012AMINO ACID SIGNALING

Cell 149(2), 410–424

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

Han JM, Jeong SJ, Park MC, et al.

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