Full publication list

Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice

Nature Communications,17, 9805, 2026

YC Yu, Y Sung, SH Lim, JA Kwon, MJ Lee, HY Kim, SH Kim, KL Kim, DS Min, HC Yoo, JM Han*

Metabolic networks in the tumor microenvironment: roles of amino acid and lipid metabolism pathways in cancer progression and therapy

Experimental & Molecular Medicine, 58, 1128-1148, 2026

Y Sung, DK Kim, JS Kim SJ Kim, JH Kim*, JM Han*

Biotransformation of allium sulfur metabolites by Proteus mirabilis yields cepathiosoxide, a trithiabicyclic sulfoxide

Organic Letters, 28, 3458-3462, 2026

J Lee, Y Sung, Y Nam, JM Han, S Um*, SH Kim*

Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var

Nature Communications, 16, 9690, 2025

Y Sung, YC Yu, M Lee, S Lim, Y Lee, M Kang, D Kwon, A Parajulee, J Choi, DS Min, K Kim, W Namkung, YH Kim, SM Woo, ND Kim, HC Yoo, JM Han*

Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer

Experimental & Molecular Medicine, 57, 910-924, 2025

HJ Lee, SH Lim, H Lee, JM Han, DS Min*

PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways

Experimental & Molecular Medicine, 56, 1479-1487, 2024

SH Lim, H Lee, HJ Lee, K Kim, J Choi, JM Han, DS Min*

Nutrient sensors and their crosstalk

Experimental & Molecular Medicine, 55, 1076-1089, 2023

Y Sung, YC Yu, JM Han*

Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer

Cancer Research. 83(5): 735-752

SJ Park, HC Yoo, E Ahn, E Luo, Y Kim, Y Sung, YC Yu, K Kim, DS Min, HS Lee, GS Hwang, TJ Ahn, JJ Choi, SM Bang, JM Han*

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

Nature Communications, 13, 2904, 2022

K Kim, HC Yoo, BG Kim, S Kim, Y Sung, I Yoon, YC Yu, SJ Park, JH Kim, K Myung, KY Hwang, S Kim, JM Han*

Functional and pathologic association of aminoacyl-tRNA synthetases with cancer

Experimental & Molecular Medicine, 54, 553-566, 2022

Y Sung, I Yoon, JM Han*, S Kim*

Amino Acid Metabolism in Cancer Drug Resistance

Cells, 11(1), 140, 2022

HC Yoo, JM Han*

Structure-based Modification of Pyrazolone Derivatives to Inhibit mTORC1 by Targeting the Leucyl-tRNA Synthetase-RagD Interaction

Bioorganic Chemistry, 112, 104907, 2021

JH Kim, K Jung, C Lee, D Song, K Kim, HC Yoo, SJ Park, JS Kang, K-R Lee, S Kim, JM Han, G Han*

Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation

Cell Reports, 35(4): 109031, 2021

S Kim, I Yoon, J Son, J Park, K Kim, J-H Lee, SY Park, BS Kang, JM Han, KY Hwang*, S Kim*

Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer

EBioMedicine, 65: 103218, 2021

HS Lee, E Kim, J Lee, SJ Park, HK Hwang, CH Park, S-Y Jo, CM Kang, S-M Hong, H Kang, JH Jo, IR Cho, MJ Chung, JY Park, SW Park, SY Song, JM Han, S kim, S Bang*

Aminoacyl-tRNA Synthetases and amino acid signaling

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1868(1):118889, 2021. (*Co-corresponding)

YC Yu, JM Han*, S Kim*

Most-cited publication from our lab

Glutamine reliance in cell metabolism

Experimental & Molecular Medicine, 52, 1496-1516, 2020

HC Yoo, YC Yu, Y Sung, JM Han*

A variant of SLC1A5 is a Mitochondrial Glutamine Transporter for metabolic reprogramming in cancer cells

Cell Metabolism, 31(2):267-283, 2020

HC Yoo, SJ Park, M Nam, J Kang, K Kim, JH Yeo, JK Kim, Y Heo, HS Lee, MY Lee, CW Lee, JS Kang, YH Kim, JN Lee, J Choi, GS Hwang, S Bang, JM Han*

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

Science, 367(6474):205-210, 2020

I Yoon, M Nam, HK Kim, HS Moon, S Kim, J Jang, JA Song, SJ Jeong, SB Kim, S Cho, Y Kim, J Lee, WS Yang, HC Yoo, K Kim, MS Kim, A Yang, K Cho, HS Park, GS Hwang, JM Han, KY Hwang, JH Kim, S Kim

Fluorescent 1,4-Naphthoquinones Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains

ACS Chemical Neuroscience, 10(6):3031-3044, 2019

N Shin, H Jeon, Y Jung, S Baek, S Lee, HC Yoo, GH Bae, K Park, S-H Yang, JM Han, I Kim, Y Kim

Non-translational function of Leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration

Journal of Clinical Investigation, 15;129(5):2088-2093, 2019

K Son, J-S You, M-S Yoon, JH Kim, NK Khanna, A Banerjee, SA Martinis, G Han, JM Han, S Kim, J Chen

Therapeutic Effects of the Novel Leucyl-tRNA Synthetase Inhibitor BC-LI-0186 in Non-Small Cell Lung Cancer

Therapeutic Advances in Medical Oncology, 11: 1758835919846798, 2019

EY Kim, JG Lee, JM Lee, A Kim, HC Yoo, K Kim, M Lee, C Lee, G Han, JM Han*, YS Chang* (*Co-corresponding)

Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study

International Journal of Rheumatic Diseases, 00: 1-8, 2019

JS Lee, CH Im, SJ Lee, JY Choi, JM Han, S Kim, DJ Kim, T Park, EY Lee, YW Song

The HDAC6 inhibitor ACY-1215 enhances the anticancer activity of oxaliplatin in colorectal cancer cells

International Journal of Oncology, 53(2): 844-854, 2018

DH Lee, H-R Won, H-W Ryu, JM Han, SH Kwon

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway

Proc. Natl. Acad. Sci. USA, 115 (23): E5279-E5288, 2018

M Lee, JH Kim, I Yoon, C Lee, MF Sichani, JS Kang, J Kang, M Guo, KY Lee, G Han, S Kim, JM Han*

Control of Leucine-dependent mTORC1 Pathway through Chemical Intervention of Leucyl-tRNA synthetase and RagD GTPase Interaction

Nature Communications, 8(1):732, 2017. (*Co-corresponding)

JH Kim, C Lee, M Lee, H Wang, K Kim, SJ Park, I Yoon, J Jang, H Zhao, HK Kim, NH Kwon, SJ Jeong, HC Yoo, JS Yang, MY Lee, CW Lee, J yun, SJ Oh, JS Kang, SA Martinis, KY Hwang, M Guo, G Han, JM Han*, S Kim*

A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro

International Journal of Molecular Sciences, 18(3). pii: E566, 2017

MR Kim, JH Jang, CS Park, T-K Kim, Y-J Kim, J Chung, H Shim, IH Nam, JM Han, S Lee

Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia

American Journal of Human Genetics, 100(3):454-472, 2017

JS Lim, R Gopalappa, SH Kim, S Ramakrishna, M Lee, WI Kim, J Kim, SM Park, J Lee, JH Oh, HD Kim, CH Park, JS Lee, S Kim, DS Kim, JM Han, HC Kang, HH Kim, JH Lee

Post translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells

Oncogene, 36(33):4732-4738, 2017

A Motzik, E Amir, T Erlich, J Wang, B-G Kim, JM Han, J H Kim, H Nechushtan, M Guo, E Razin and S Tshori

Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling

Cell Reports, 9;16(6): 1510-1517, 2016

MS Yoon, K Son, E Arauz, JM Han, S Kim, J Chen

AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling

Cancer Research, 1;76 (15):4559-4568, 2016

MK Yum, JS Kang, AE Lee, YW Jo, JY Seo, HA Kim, YY Kim, JW Seong, EB Lee, JH Kim, JM Han, S Kim, YY Kong

Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor Suppressive Interaction with Smurf2

Cancer Research, 76(11): 3422-3436, 2016

DG Kim, JY Lee, JH Lee, HY Cho, BS Kang, SY Jang, MH Kim, M Guo, JM Han, SJ Kim, S Kim

Direct regulation of TLR5 expression by caveolin-1

Molecules and Cells, 38(12): 1111-1117, 2015

JS Lim, KC Nguyen, JM Han, IS Jang, C Fabian, KA Cho

Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence

Aging Cell, 14(5): 907-915, 2015

JS Lim JS, KC Nguyen, CT Nguyen, IS Jang, JM Han, C Fabian, SE Lee, JH Rhee, KA Cho

AIMP1 negatively regulates adipogenesis by inhibiting PPARgamma

Journal of Cell Science. 127(Pt 20):4483-93, 2014. (*Co-corresponding)

JH Kim, JH Lee, MC Park, I Yoon, K Kim, M Lee, HS Choi, JM Han*, S Kim*

Chemical inhibition of pronetastatic lysyl-tRNA synthetase-laminin receptor interaction

Nature Chemical Biology. 10(1): 29-34, 2014

DG Kim, JY Lee, NH Kwon, P Fang, Q Zhang, J Wang, NL Young, M Guo, HY Cho, AU Mushtaq, YH Jeon, JW Choi, JM Han, HW Kang, JE Joo, Y Hur, W Kang, H Yang, DH Nam, MS Lee, JW Lee, ES Kim, A Moon, K Kim, D Kim, EJ Kang, Y Moon, KH Rhee, BW Han, JS Yang, G Han, WS Yang, C Lee, MW Wang, S Kim

Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases

Topics in current chemistry. 344:119-144, 2014. (*Corresponding)

JH Kim, JM Han*, S Kim

Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumor regression

Biochemical Journal. 454(3):411-6, 2013

HS Lee, DG Kim, YS Oh, NH Kwon, JY Lee, D Kim, SH Park, JH Song, S Lee, JM Han, BJ Park, J Lee, S Kim

Multiple reaction monitoring of multiple low-abundance transcription factors in whole lung cancer cell lysates

Journal of Proteome Research. 12(6):2582-2596, 2013

JS Kim, Y Lee, MY Lee, J Shin, JM Han, EG Yang, M-H Yu, S Kim, D Hwang, C Lee

Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43

Journal of Cell Science. 125(Pt 19):4620-9, 2012

HS Kwon, MC Park, DG Kim, KW Jo, YW Park, JM Han, S Kim

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

Cell, 149(2):410-24, 2012

JM Han, SJ Jeong, MC Park, G Kim, NH Kwon, SH Ha, SH Ryu, S Kim

Secreted Human Glycyl- tRNA synthetase Implicated in Defense Against ERK-Activated Tumorigenesis

Proc. Natl. Acad. Sci. USA, 109(11): E640-7, 2012

MC Park, T Kang, D Jin, JM Han, SB Kim, YC Park, K Cho, YW Park, W He, XL Yang, P Schimmel, S Kim

Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of AIMP3

Proc. Natl. Acad. Sci. USA, 108(49): 19635-40, 2011

NH Kwon, T Kang, JY Lee, HH Kim, HR Kim, J Hong, YS Oh, JM Han, MJ Ku, SY Lee, S Kim

Cancer-associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis

PLoS Genetics, 7(3): e1001351, 2011

JW Choi, DG Kim, A Lee, HR Kim, JY Lee, NH Kwon, YK Shin, S Hwang, S Chang, M Cho, Y Choi, J Kim, SH Oh, B Kim, S Kim, H Jeon, JY Park, HP Kang, BJ Park, JM Han, S Kim

Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemikine activity towards human endothelial cells

PLoS Neglected Tropical Diseases, 5(11):e1398, 2011

M Castro, F Miro, JM Han, S Kim, A Celada, LR Pouplana

Enhancement of Toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells

Immunology, 134(1):73-81, 2011

E Kim, HJ Hong, D Cho, JM Han, S Kim, TS Kim

Importin beta plays an essential role in the regulation of the LysRS-Ap4A pathway in immunologically activated mast cells

Molecular and Cellular Biology. 31(10):2111-2121, 2011

I Carmi-Levy, A Motzik, Y Ofir-Birin, Z Yagil, CM Yang, DM Kemeny, JM Han, S Kim, G Kay, H Nechushtan, R Suzuki, J Rivera, E Razin

Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease

PLoS One 5(3): e9792, 2010

JM Han, NH Kwon, JY Lee, SJ Jeong, HJ Jung, HR Kim, Z Li, S Kim

Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1(AIMP1/p43)

Cancer Letters. 287(2):157-164, 2010

JM Han, H Myung, S Kim

Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation

Biochemical and Biophysical Research Communications. 397(1): 100-105, 2010

G Kim, JM Han, S Kim

Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells

Aging Cell. 9(2): 243-251, 2010

JS Lim, HE Choy, SC Park, JM Han, IS Jang, KA Cho

LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression

Molecular Cell. 34(5):603-611,2009

N Yannay-Cohen, I Carmi-Levy, G Kay, CM Yang, JM Han, DM Kemeny, S Kim, H Nechushtan, E Razin

AIMP2/p38 promotes TNF-alpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2

Journal of Cell Science. 122 (Pt 15): 2710-2715, 2009

JW Choi, DG Kim, MC Park, JY Um, JM Han, SG Park, EC Choi, S Kim

Caveolae-mediated entry of Salmonella typhimurium in a human M-cell model

Biochemical and Biophysical Research Communications. 390(4):1322-7, 2009

JS Lim, HS Na, HC Lee, HE Choy, SC Park, JM Han, KA Cho

AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53

Proc. Natl. Acad. Sci. USA 105(32):11206-11211, 2008

JM Han, BJ Park, SG Park, YS Oh, SJ Choi, SW Lee, SK Hwang, SH Chang, MH Cho, S Kim

AIMP1/p43 downregulates TGF-beta signaling via tabilization of smurf2

Biochemical and Biophysical Research Communications, 371(3):395-400, 2008. (*equal contribution)

YS Lee*, JM Han*, SH Son, JW Choi, EJ Jeon, SC Bae, YI Park, S Kim

p43/AIMP1 Suppresses Cell Surface Presentation of gp96/TRA1 for Immunologic Tolerance: Its Pathological Implications for Systemic Lupus Erythematosus

American Journal of Pathology. 170(6):2042-2054, 2007

JM Han, SG Park, B Liu, BJ Park, JY Kim, Z Li, S Kim

Hierarchical Network between the Components of Multi-tRNA Synthetase Complex: Functional Implications for Complex Formation

Journal of Biological Chemistry. 281(50):38663-38667, 2006

JM Han, MJ Lee, S Kim

Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43/AIMP1

Biochemical and Biophysical Research Communications. 342(1):113-118, 2006

JM Han, SG Park, Y Lee, S Kim

Anti-tumor activity of novel human cytokine AIMP1 in in vivo tumor model

Molecules and Cells. 21 (2):213-217, 2006

YS Lee, JM Han, T Kang, YI Park, S Kim

Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity

Journal of Cell Science. 118 (Pt 19):4405-4413, 2005

JS Lee, JH Kim, IH Jang, HS Kim, JM Han, A Kazlauskas, H Yagisawa, PG Suh, SH Ryu

Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation

Nature Genetics. 34(3):330-336, 2003

MJ Kim, BJ Park, YS Kang, HJ Kim, JH Park, JW Kang, SW Lee, JM Han, HW Lee, S Kim

Molecular network and functional implications of macromolecular tRNA synthetase complex

Biochemical and Biophysical Research Communications. 303(4):985-993, 2003

JM Han, JY Kim, S Kim

Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling

Molecular Biology of the Cell. 13(11):3976-3988, 2002

JM Han, Y Kim, JS Lee, BD Lee, PG Suh, SH Ryu

Phosphorylation-dependent regulation of Phospholipase D2 by Protein Kinase C in PC12 pheochromocytoma cells

Journal of Biological Chemistry. 277(10):8290-7, 2002

JM Han, JH Kim, SD Lee, BD Lee, Y Kim, PG Suh, SH Ryu

Carbachol-induced phosphorylation of Phospholipase D1 through Protein Kinase C is required for the activation in COS-7 cells

Journal of biochemistry and molecular biology. 34(2), 182-187, 2001

BD Lee, Y Kim, JM Han, PG Suh, SH Ryu

Dual requirement for Rho and protein kinase C in direct activation of phospholipase D1 through G-protein coupled receptor signalling

Molecular Biology of the Cell. 11(12), 4359-4368, 2000

G Du, AM Altshuller, Y Kim, JM Han, SH Ryu, AJ Morris, MA Frohman

Phospholipase D1 is phosphorylated and activated by protein kinase C in caveolin-enriched microdomains within plasma membrane

Journal of Biological Chemistry. 275(18), 13621-13627, 2000

Y Kim, JM Han, BR Han, KA Lee, JH Kim, BD Lee, IH Jang, PG Suh, SH Ryu

Phospholipase D2 Activity Suppresses Hydrogen Peroxide‐Induced Apoptosis in PC12 Cells

Journal of Neurochemistry, 75(3), 1053-1059, 2000

SD Lee, BD Lee, JM Han, JH Kim, Y Kim, PG Suh, SH Ryu

Identification of Multiple Phosphorylation Sites of Phospholipase D1 by Protein Kinase C

Biochemistry, 38(32):10344-10351, 1999

Y Kim, JM Han, SD Lee, JB Park, C Chung, TG Lee, JH Kim, PG Suh, SH Ryu

Phospholipase D1 in Caveolae : Regulation by Protein Kinase Ca and Caveolin-1

Biochemistry, 38(12):3763-3769, 1999

JH Kim, JM Han, S Lee, Y Kim, TG Lee, JB Park, SD Lee, PG Suh, SH Ryu

Phospholipase D1 is located and activated by protein kinase Ca in the plasma membrane in 3Y1 fibroblast cell

BBA Molecular and Cell Biology of Lipids, 1436(3), 319-330, 1999

Y Kim, JE Kim, SD Lee, TG Lee, JH Kim, JB Park, JM Han, SK Jang, PG Suh, SH Ryu

Activation of Phospholipase D1 by direct interaction with ADP-ribosylation factor1 and RalA

FEBS Letters, 430(3), 231-235, 1998

JH Kim, SD Lee, JM Han, TG Lee, Y Kim, JB Park, JD Lambeth, PG Suh, SH Ryu

Generation of the replication-competent human immunodeficiency virus type-1 which expresses a jellyfish green fluorescent protein

Biochemical and Biophysical Research Communications. 233(1), 288-292, 1997

AH Lee, JM Han, YC Sung