2023
Y Sung, YC Yu, JM Han*, Nutrient sensors and their crosstalk,
Experimental & Molecular Medicine, 55, 1076-1089, 2023. (IF=12.178)
SJ Park, HC Yoo, E Ahn, E Luo, Y Kim, Y Sung, YC Yu, K Kim, DS Min, HS Lee, GS Hwang, TJ Ahn, JJ Choi, SM Bang, JM Han*, Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer,
Cancer Research. 83(5): 735-752. (IF=13.312)
2022
K Kim, HC Yoo, BG Kim, S Kim, Y Sung, I Yoon, YC Yu, SJ Park, JH Kim, K Myung, KY Hwang, S Kim, JM Han*, O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine,
Nature Communications, 13, 2904, 2022. (IF=17.694)
Selected as the Featured Article of "Structural biology, biochemistry and biophysics" Editors' Highlights of Nature Communications
Y Sung, I Yoon, JM Han*, S Kim*, Functional and pathologic association of aminoacyl-tRNA synthetases with cancer,
Experimental & Molecular Medicine, 54, 553-566, 2022. (IF=12.178)
HC Yoo, JM Han*, Amino Acid Metabolism in Cancer Drug Resistance,
Cells, 11(1), 140, 2022. (IF=7.666)
2021
JH Kim, K Jung, C Lee, D Song, K Kim, HC Yoo, SJ Park, JS Kang, K-R Lee, S Kim, JM Han, G Han*, Structure-based Modification of Pyrazolone Derivatives to Inhibit mTORC1 by Targeting the Leucyl-tRNA Synthetase-RagD Interaction, Bioorganic Chemistry, 112, 104907, 2021. (IF=5.307)
S Kim, I Yoon, J Son, J Park, K Kim, J-H Lee, SY Park, BS Kang, JM Han, KY Hwang*, S Kim*, Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation,
Cell Reports, 35(4): 109031, 2021. (IF=9.995)
HS Lee, E Kim, J Lee, SJ Park, HK Hwang, CH Park, S-Y Jo, CM Kang, S-M Hong, H Kang, JH Jo, IR Cho, MJ Chung, JY Park, SW Park, SY Song, JM Han, S kim, S Bang*, Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer,
EBioMedicine, 65: 103218, 2021. (IF=11.205)
YC Yu, JM Han*, S Kim*. Aminoacyl-tRNA Synthetases and amino acid signaling,
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1868(1):118889, 2021. (IF=5.011) (*Co-corresponding)
2020
HC Yoo, YC Yu, Y Sung, JM Han*. Glutamine reliance in cell metabolism,
Experimental & Molecular Medicine, 52, 1496-1516, 2020. (IF=12.178)
HC Yoo, SJ Park, M Nam, J Kang, K Kim, JH Yeo, JK Kim, Y Heo, HS Lee, MY Lee, CW Lee, JS Kang, YH Kim, JN Lee, J Choi, GS Hwang, S Bang, JM Han*. A variant of SLC1A5 is a Mitochondrial Glutamine Transporter for metabolic reprogramming in cancer cells, Cell Metabolism, 31(2):267-283, 2020. (IF=31.373)
Selected as the Featured Article of Volume 31, Issue 2 of Cell Metabolism Journal
Highlighted in ZE Stine, CV Dang. "Glutamine Skipping the Q into the Mitochondria" (ZE Stine, CV Dang., Trends in Molecular Medicine 2020)
I Yoon, M Nam, HK Kim, HS Moon, S Kim, J Jang, JA Song, SJ Jeong, SB Kim, S Cho, Y Kim, J Lee, WS Yang, HC Yoo, K Kim, MS Kim, A Yang, K Cho, HS Park, GS Hwang, JM Han, KY Hwang, JH Kim, S Kim. Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1, Science, 367(6474):205-210, 2020. (IF=63.798)
Highlighted in “A tRNA synthetase in metabolic control” (L. Bryan Ray et al., Science 2020) and “A sugary input to leucine sensing” (Elyssa Lehman et al., Science 2020).
2019
N Shin, H Jeon, Y Jung, S Baek, S Lee, HC Yoo, GH Bae, K Park, S-H Yang, JM Han, I Kim, Y Kim, Fluorescent 1,4-Naphthoquinones Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains,
ACS Chemical Neuroscience, 10(6):3031-3044, 2019. (IF=5.780)
K Son, J-S You, M-S Yoon, JH Kim, NK Khanna, A Banerjee, SA Martinis, G Han, JM Han, S Kim, J Chen, Non-translational function of Leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration,
Journal of Clinical Investigation, 15;129(5):2088-2093, 2019. (IF=19.486)
EY Kim, JG Lee, JM Lee, A Kim, HC Yoo, K Kim, M Lee, C Lee, G Han, JM Han*, YS Chang* (*Co-corresponding), Therapeutic Effects of the Novel Leucyl-tRNA Synthetase Inhibitor BC-LI-0186 in Non-Small Cell Lung Cancer, Therapeutic Advances in Medical Oncology, 11: 1758835919846798, 2019. (IF=5.485)
JS Lee, CH Im, SJ Lee, JY Choi, JM Han, S Kim, DJ Kim, T Park, EY Lee, YW Song, Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study,
International Journal of Rheumatic Diseases, 00: 1-8, 2019. (IF=2.560)
2018
DH Lee, H-R Won, H-W Ryu, JM Han, SH Kwon, The HDAC6 inhibitor ACY-1215 enhances the anticancer activity of oxaliplatin in colorectal cancer cells
International Journal of Oncology, 53(2): 844-854, 2018. (IF=5.884)
M Lee, JH Kim, I Yoon, C Lee, MF Sichani, JS Kang, J Kang, M Guo, KY Lee, G Han, S Kim, JM Han*, Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway,
Proc. Natl. Acad. Sci. USA, 115 (23): E5279-E5288, 2018. (IF=12.779)
2017
JH Kim, C Lee, M Lee, H Wang, K Kim, SJ Park, I Yoon, J Jang, H Zhao, HK Kim, NH Kwon, SJ Jeong, HC Yoo, JS Yang, MY Lee, CW Lee, J yun, SJ Oh, JS Kang, SA Martinis, KY Hwang, M Guo, G Han, JM Han*, S Kim*, Control of Leucine-dependent mTORC1 Pathway through Chemical Intervention of Leucyl-tRNA synthetase and RagD GTPase Interaction
Nature Communications, 8(1):732, 2017. (IF=17.694) (*Co-corresponding)
MR Kim, JH Jang, CS Park, T-K Kim, Y-J Kim, J Chung, H Shim, IH Nam, JM Han, S Lee, A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro
International Journal of Molecular Sciences, 18(3). pii: E566, 2017. (IF=6.208)
JS Lim, R Gopalappa, SH Kim, S Ramakrishna, M Lee, WI Kim, J Kim, SM Park, J Lee, JH Oh, HD Kim, CH Park, JS Lee, S Kim, DS Kim, JM Han, HC Kang, HH Kim, JH Lee, Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia
American Journal of Human Genetics, 100(3):454-472, 2017. (IF=11.043)
A Motzik, E Amir, T Erlich, J Wang, B-G Kim, JM Han, J H Kim, H Nechushtan, M Guo, E Razin and S Tshori, Post translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells
Oncogene, 36(33):4732-4738, 2017. (IF=8.756)
2016
MS Yoon, K Son, E Arauz, JM Han, S Kim, J Chen, Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling
Cell Reports, 9;16(6): 1510-1517, 2016. (IF=9.995)
MK Yum, JS Kang, AE Lee, YW Jo, JY Seo, HA Kim, YY Kim, JW Seong, EB Lee, JH Kim, JM Han, S Kim, YY Kong, AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling
Cancer Research, 1;76 (15):4559-4568, 2016. (IF=13.312)
DG Kim, JY Lee, JH Lee, HY Cho, BS Kang, SY Jang, MH Kim, M Guo, JM Han, SJ Kim, S Kim, Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor Suppressive Interaction with Smurf2
Cancer Research, 76(11): 3422-3436, 2016. (IF=13.312)
2015
JS Lim, KC Nguyen, JM Han, IS Jang, C Fabian, KA Cho, Direct regulation of TLR5 expression by caveolin-1
Molecules and Cells, 38(12): 1111-1117, 2015. (IF=4.250)
JS Lim JS, KC Nguyen, CT Nguyen, IS Jang, JM Han, C Fabian, SE Lee, JH Rhee, KA Cho, Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence
Aging Cell, 14(5): 907-915, 2015. (IF=11.005)
2014
JH Kim, JH Lee, MC Park, I Yoon, K Kim, M Lee, HS Choi, JM Han*, S Kim*, AIMP1 negatively regulates adipogenesis by inhibiting PPARgamma
Journal of Cell Science. 127(Pt 20):4483-93, 2014. (*Co-corresponding) (IF=5.235)
DG Kim, JY Lee, NH Kwon, P Fang, Q Zhang, J Wang, NL Young, M Guo, HY Cho, AU Mushtaq, YH Jeon, JW Choi, JM Han, HW Kang, JE Joo, Y Hur, W Kang, H Yang, DH Nam, MS Lee, JW Lee, ES Kim, A Moon, K Kim, D Kim, EJ Kang, Y Moon, KH Rhee, BW Han, JS Yang, G Han, WS Yang, C Lee, MW Wang, S Kim, Chemical inhibition of pronetastatic lysyl-tRNA synthetase-laminin receptor interaction
Nature Chemical Biology. 10(1): 29-34, 2014. (IF=16.290)
JH Kim, JM Han*, S Kim, Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases
Topics in current chemistry. 344:119-144, 2014. (*Corresponding) (IF=8.905)
2013
HS Lee, DG Kim, YS Oh, NH Kwon, JY Lee, D Kim, SH Park, JH Song, S Lee, JM Han, BJ Park, J Lee, S Kim, Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumor regression
Biochemical Journal. 454(3):411-6, 2013. (IF=5.370)
JS Kim, Y Lee, MY Lee, J Shin, JM Han, EG Yang, M-H Yu, S Kim, D Hwang, C Lee, Multiple reaction monitoring of multiple low-abundance transcription factors in whole lung cancer cell lysates
Journal of Proteome Research. 12(6):2582-2596, 2013. (IF=5.001)
2012
HS Kwon, MC Park, DG Kim, KW Jo, YW Park, JM Han, S Kim, Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43
Journal of Cell Science. 125(Pt 19):4620-9, 2012. (IF=5.235)
JM Han, SJ Jeong, MC Park, G Kim, NH Kwon, SH Ha, SH Ryu, S Kim, Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Cell, 149(2):410-24, 2012. (IF=66.850)
Highlighted in “Most-read" (Faculty of 1000 Biology) and "Leucyl-tRNA synthetase: double duty in amino acid sensing" (R.V. Han and M.N. Hall., Cell Research 2012)
Referred as "From Bench to Bedside" (Cell Podcast, 2012) and "Hijacking Leucyl-tRNA synthetase for Amino Acid-Dependent Regulation of TORC1" (N Segev and N Hay., Previews in Molecular Cell 2012)
Selected as Editor’s Choice in "I Love Leucine" (W. Wong., Science Signaling 2012)
MC Park, T Kang, D Jin, JM Han, SB Kim, YC Park, K Cho, YW Park, W He, XL Yang, P Schimmel, S Kim, Secreted Human Glycyl- tRNA synthetase Implicated in Defense Against ERK-Activated Tumorigenesis
Proc. Natl. Acad. Sci. USA, 109(11): E640-7, 2012. (IF=12.779)
Highlighted in “Editor’s Choice” (Science Signaling 2012).
2011
NH Kwon, T Kang, JY Lee, HH Kim, HR Kim, J Hong, YS Oh, JM Han, MJ Ku, SY Lee, S Kim, Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of AIMP3
Proc. Natl. Acad. Sci. USA, 108(49): 19635-40, 2011. (IF=12.779)
JW Choi, DG Kim, A Lee, HR Kim, JY Lee, NH Kwon, YK Shin, S Hwang, S Chang, M Cho, Y Choi, J Kim, SH Oh, B Kim, S Kim, H Jeon, JY Park, HP Kang, BJ Park, JM Han, S Kim, Cancer-associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis
PLoS Genetics, 7(3): e1001351, 2011. (IF=6.020)
M Castro, F Miro, JM Han, S Kim, A Celada, LR Pouplana, Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemikine activity towards human endothelial cells
PLoS Neglected Tropical Diseases, 5(11):e1398, 2011. (IF=4.781)
E Kim, HJ Hong, D Cho, JM Han, S Kim, TS Kim, Enhancement of Toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells
Immunology, 134(1):73-81, 2011. (IF=7.215)
I Carmi-Levy, A Motzik, Y Ofir-Birin, Z Yagil, CM Yang, DM Kemeny, JM Han, S Kim, G Kay, H Nechushtan, R Suzuki, J Rivera, E Razin, Importin beta plays an essential role in the regulation of the LysRS-Ap4A pathway in immunologically activated mast cells
Molecular and Cellular Biology. 31(10):2111-2121, 2011. (IF=5.124)
2010
JM Han, NH Kwon, JY Lee, SJ Jeong, HJ Jung, HR Kim, Z Li, S Kim, Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease
PLoS One 5(3): e9792, 2010. (IF=3.752)
JM Han, H Myung, S Kim, Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1(AIMP1/p43)
Cancer Letters. 287(2):157-164, 2010. (IF=9.756)
G Kim, JM Han, S Kim, Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation
Biochemical and Biophysical Research Communications. 397(1): 100-105, 2010. (IF=3.322)
JS Lim, HE Choy, SC Park, JM Han, IS Jang, KA Cho, Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells
Aging Cell. 9(2): 243-251, 2010. (IF=11.005)
2009
N Yannay-Cohen, I Carmi-Levy, G Kay, CM Yang, JM Han, DM Kemeny, S Kim, H Nechushtan, E Razin, LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression
Molecular Cell. 34(5):603-611,2009. (IF=19.328)
JW Choi, DG Kim, MC Park, JY Um, JM Han, SG Park, EC Choi, S Kim, AIMP2/p38 promotes TNF-alpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2,
Journal of Cell Science. 122 (Pt 15): 2710-2715, 2009. (IF=5.235)
JS Lim, HS Na, HC Lee, HE Choy, SC Park, JM Han, KA Cho, Caveolae-mediated entry of Salmonella typhimurium in a human M-cell model
Biochemical and Biophysical Research Communications. 390(4):1322-7, 2009. (IF=3.322)
2008
JM Han, BJ Park, SG Park, YS Oh, SJ Choi, SW Lee, SK Hwang, SH Chang, MH Cho, S Kim, AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53
Proc. Natl. Acad. Sci. USA 105(32):11206-11211, 2008. (IF=12.779)
YS Lee*, JM Han*, SH Son, JW Choi, EJ Jeon, SC Bae, YI Park, S Kim, AIMP1/p43 downregulates TGF-beta signaling via tabilization of smurf2
Biochemical and Biophysical Research Communications, 371(3):395-400, 2008. (*equal contribution) (IF=3.322)
2007
JM Han, SG Park, B Liu, BJ Park, JY Kim, Z Li, S Kim, p43/AIMP1 Suppresses Cell Surface Presentation of gp96/TRA1 for Immunologic Tolerance: Its Pathological Implications for Systemic Lupus Erythematosus
American Journal of Pathology. 170(6):2042-2054, 2007. (IF=5.770)
2006
JM Han, MJ Lee, S Kim, Hierarchical Network between the Components of Multi-tRNA Synthetase Complex: Functional Implications for Complex Formation
Journal of Biological Chemistry. 281(50):38663-38667, 2006. (IF=5.486)
JM Han, SG Park, Y Lee, S Kim, Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43/AIMP1
Biochemical and Biophysical Research Communications. 342(1):113-118, 2006. (IF=3.322)
YS Lee, JM Han, T Kang, YI Park, S Kim, Anti-tumor activity of novel human cytokine AIMP1 in in vivo tumor model
Molecules and Cells. 21 (2):213-217, 2006. (IF=4.250)
2005
JS Lee, JH Kim, IH Jang, HS Kim, JM Han, A Kazlauskas, H Yagisawa, PG Suh, SH Ryu, Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity
Journal of Cell Science. 118 (Pt 19):4405-4413, 2005 (IF=5.235)
2003
MJ Kim, BJ Park, YS Kang, HJ Kim, JH Park, JW Kang, SW Lee, JM Han, HW Lee, S Kim, Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation
Nature Genetics. 34(3):330-336, 2003. (IF=41.379)
JM Han, JY Kim, S Kim, Molecular network and functional implications of macromolecular tRNA synthetase complex
Biochemical and Biophysical Research Communications. 303(4):985-993, 2003. (IF=3.322)
2002
JM Han, Y Kim, JS Lee, BD Lee, PG Suh, SH Ryu, Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling
Molecular Biology of the Cell. 13(11):3976-3988, 2002.
JM Han, JH Kim, SD Lee, BD Lee, Y Kim, PG Suh, SH Ryu, Phosphorylation-dependent regulation of Phospholipase D2 by Protein Kinase C in PC12 pheochromocytoma cells
Journal of Biological Chemistry. 277(10):8290-7, 2002.
2001
BD Lee, Y Kim, JM Han, PG Suh, SH Ryu, Carbachol-induced phosphorylation of Phospholipase D1 through Protein Kinase C is required for the activation in COS-7 cells
Journal of biochemistry and molecular biology. 34(2), 182-187, 2001.
2000
G Du, AM Altshuller, Y Kim, JM Han, SH Ryu, AJ Morris, MA Frohman, Dual requirement for Rho and protein kinase C in direct activation of phospholipase D1 through G-protein coupled receptor signalling
Molecular Biology of the Cell. 11(12), 4359-4368, 2000.
Y Kim, JM Han, BR Han, KA Lee, JH Kim, BD Lee, IH Jang, PG Suh, SH Ryu, Phospholipase D1 is phosphorylated and activated by protein kinase C in caveolin-enriched microdomains within plasma membrane
Journal of Biological Chemistry. 275(18), 13621-13627, 2000.
SD Lee, BD Lee, JM Han, JH Kim, Y Kim, PG Suh, SH Ryu, Phospholipase D2 Activity Suppresses Hydrogen Peroxide‐Induced Apoptosis in PC12 Cells
Journal of Neurochemistry, 75(3), 1053-1059, 2000.
1999
Y Kim, JM Han, SD Lee, JB Park, C Chung, TG Lee, JH Kim, PG Suh, SH Ryu, Identification of Multiple Phosphorylation Sites of Phospholipase D1 by Protein Kinase C
Biochemistry, 38(32):10344-10351, 1999.
JH Kim, JM Han, S Lee, Y Kim, TG Lee, JB Park, SD Lee, PG Suh, SH Ryu, Phospholipase D1 in Caveolae : Regulation by Protein Kinase Ca and Caveolin-1
Biochemistry, 38(12):3763-3769, 1999.
Y Kim, JE Kim, SD Lee, TG Lee, JH Kim, JB Park, JM Han, SK Jang, PG Suh, SH Ryu, Phospholipase D1 is located and activated by protein kinase Ca in the plasma membrane in 3Y1 fibroblast cell
BBA Molecular and Cell Biology of Lipids, 1436(3), 319-330, 1999.
1998
JH Kim, SD Lee, JM Han, TG Lee, Y Kim, JB Park, JD Lambeth, PG Suh, SH Ryu, Activation of Phospholipase D1 by direct interaction with ADP-ribosylation factor1 and RalA
FEBS Letters, 430(3), 231-235, 1998.
1997
AH Lee, JM Han, YC Sung, Generation of the replication-competent human immunodeficiency virus type-1 which expresses a jellyfish green fluorescent protein
Biochemical and Biophysical Research Communications. 233(1), 288-292, 1997.