NUTRIENT SIGNALING
How do cells sense nutrients?
We study noncanonical functions of aminoacyl-tRNA synthetases, focusing on how LARS1 links nutrient availability to mTORC1 signaling and metabolism.
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How does glutamine transport reshape cancer?
We investigate SLC1A5_var-mediated mitochondrial glutamine transport and its connections to metabolic reprogramming, tumor growth and hypoxia-associated chemoresistance.
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How does metabolism regulate immune memory?
We explore the link between mitochondrial glutamine metabolism and macrophage trained immunity, and investigate metabolic control of antitumor protection in experimental models.
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Can metabolic vulnerabilities become therapeutic targets?
We combine chemical biology, structural modeling and experimental validation to target nutrient sensing and transport, exploring cancer glutamine dependency as a therapeutic opportunity.
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