Publication
Patents
Invited Lectures
Priz & Award
for Student
2012
HS Kwon, MC Park, DG Kim, KW Jo, YW Park, JM Han, S Kim, Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43, J. Cell Sci. 125: 4620-4629, 2012. (IF=5.877)
JM Han, SJ Jeong, MC Park, G Kim, NH Kwon, SH Ha, SH Ryu, S Kim, Leucyl-tRNA Synthetase Serves as Intracellular Leucine Sensor for mTORC1 Signaling Pathway, Cell, 149, 410-424, 2012 (IF=31.957)
(Highlighted as “Most-read”, Faculty of 1000 Biology; Referred to Cell Podcast, From
Bench to Bedside, April 2012; Referred to Previews in Molecular Cell, N Segev and
N Hay, Hijacking Leucyl-tRNA synthetase for Amino Acid-Dependent Regulation of
TORC1, 46, 4-6, 2012; Research highlight in Cell Research, R.V. Han and M.N. Hall,
Leucyl-tRNA synthetase: double duty in amino acid sensing, online publication 24,
April, 2012; Editor’s Choice in Science Signaling, W. Wong, I Love Leucine, 5 (222),
ec121, 2012)
MC Park, T Kang, D Jin, JM Han, SB Kim, YC Park, K Cho, YW Park, W He, XL Yang, P Schimmel, S Kim, Secreted Human Glycyl- tRNA synthetase Implicated in Defense Against ERK-Activated Tumorigenesis, Proc. Natl. Acad. Sci. USA, 109(11): E640-7, 2012 (IF=9.737)
(Highlighted as “Editor’s Choice”, Science Signaling, Vol.5, Issue216, p. ec83)
NH Kwon, T Kang, JY Lee, HH Kim, HR Kim, J Hong, YS Oh, JM Han, MJ Ku, SY Lee, S Kim, Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of AIMP3, Proc. Natl. Acad. Sci. USA, 108(49): 19635-40, 2011.
JW Choi, DG Kim, A Lee, HR Kim, JY Lee, NH Kwon, YK Shin, S Hwang, S Chang, M Cho, Y Choi, J Kim, SH Oh, B Kim, S Kim, H Jeon, JY Park, HP Kang, BJ Park, JM Han, S Kim, Cancer-associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis, PLoS Genetics, 7(3): e1001351, 2011.
M Castro, F Miro, JM Han, S Kim, A Celada, LR Pouplana, Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemikine activity towards human endothelial cells, PLoS Neglected Tropical Diseases, 5(11):e1398, 2011
E Kim, HJ Hong, D Cho, JM Han, S Kim, TS Kim, Enhancement of Toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells, Immunology 134(1):73-81, 2011
I Carmi-Levy, A Motzik, Y Ofir-Birin, Z Yagil, CM Yang, DM Kemeny, JM Han, S Kim, G Kay, H Nechushtan, R Suzuki, J Rivera, E Razin, Importin beta plays an essential role in the regulation of the LysRS-Ap4A pathway in immunologically activated mast cells, Mol. Cell. Biol. 31(10):2111-2121, 2011
2011
JM Han, NH Kwon, JY Lee, SJ Jeong, HJ Jung, HR Kim, Z Li, S Kim, Identification of gp96 as a Novel Target for Treatment of Autoimmune Disease. PLoS One 5(3): e9792, 2010.
JM Han, H Myung, S Kim, Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1(AIMP1/p43), Cancer Lett. 287(2):157-164, 2010.
G Kim, JM Han, S Kim, Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation, Biochem. Biophys. Res. Commun. 397(1): 100-105, 2010
JS Lim, HE Choy, SC Park, JM Han, IS Jang, KA Cho, Caveolae-mediated entry of Salmonella typhimurium into senescent nonphagocytotic host cells, Aging Cell 9(2): 243-251, 2010
2010
N Yannay-Cohen, I Carmi-Levy, G Kay, CM Yang, JM Han, DM Kemeny, S Kim, H Nechushtan, E Razin, LysRS Serves as a Key Signaling Molecule in the Immune Response by Regulating Gene Expression, Mol. Cell 34(5):603-611,2009.
JW Choi, DG Kim, MC Park, JY Um, JM Han, SG Park, EC Choi, S Kim, AIMP2/p38 promotes TNF-alpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2,
J. Cell Sci. 122 (Pt 15): 2710-2715, 2009
JS Lim, HS Na, HC Lee, HE Choy, SC Park, JM Han, KA Cho, Caveolae-mediated entry of Salmonella typhimurium in a human M-cell model, Biochem. Biophys. Res. Commun. 390(4):1322-7, 2009
2009
JM Han, BJ Park, SG Park, YS Oh, SJ Choi, SW Lee, SK Hwang, SH Chang, MH Cho, S Kim, AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53, Proc. Natl. Acad. Sci. USA 105(32):11206-11211, 2008.
YS Lee*, JM Han*, SH Son, JW Choi, EJ Jeon, SC Bae, YI Park, S Kim, AIMP1/p43 downregulates TGF-beta signaling via tabilization of smurf2, Biochem. Biophys Res Commun, 371(3):395-400, 2008 (*equal contribution)